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Evidence-Based Nutrition & Health Research Writer: Nathaniel Pierce specializes in evidence-based writing on histamine intolerance, DAO function, and gut health. He translates peer-reviewed research into clear, trustworthy insights that support informed health decisions. Reviewed & edited under Nourishly editorial standards for accuracy and clarity.

56 Articles
Watercolor illustration of natural antihistamine and histamine support capsules with nettle, ginger, turmeric and spirulina
Natural Mast-Cell Stabilizers

Natural Antihistamine: Which Foods, Herbs and Supplements May Help?

Some natural compounds have human allergy studies, but none is proven to replace standard antihistamine medicines across allergies, hives or histamine intolerance.

Vitamin C and histamine intolerance evidence guide with vitamin-C-rich foods
DAO Cofactors, Vitamins & Minerals

Vitamin C and Histamine Intolerance: Can It Help Lower Histamine?

Human studies suggest vitamin C can influence circulating histamine, but direct evidence for treating histamine intolerance is still missing.

Quercetin for histamine intolerance with supplement bottle, red onion and apple
Natural Mast-Cell Stabilizers

Quercetin for Histamine Intolerance: Does It Actually Help?

Quercetin can inhibit mast-cell mediator release in experimental studies, but direct clinical evidence for histamine intolerance is still missing.

Tryptase test blood sample beside a stopwatch and laboratory request form
Histamine, DAO & Mast-Cell Testing

Tryptase Test: What the Blood Test Measures and What Results Mean

A tryptase result only makes sense in context: whether it was drawn during a reaction or at baseline, when it was collected, and...

Technical illustration of PMDD and histamine showing brain signaling, menstrual cycle hormones and mast-cell activity
Menstrual Cycle & Reproductive Hormones

PMDD and Histamine: Is There Really a Connection?

PMDD appears to reflect abnormal brain sensitivity to normal hormone shifts; histamine may overlap, but it has not been shown to cause the...

Technical illustration of histamine and menopause showing hormones, mast cells, gut, skin and brain
Menstrual Cycle & Reproductive Hormones

Histamine and Menopause: Can Hormonal Changes Affect Histamine Intolerance?

Menopause can change immune, vascular and mast-cell biology, but current evidence does not show that menopause directly causes dietary histamine intolerance.

Watercolor illustration of a woman tracking menstrual symptoms related to estrogen and histamine
Menstrual Cycle & Reproductive Hormones

Estrogen and Histamine: How Strong Is the Hormone Connection?

Estrogen can affect mast-cell signaling, but the popular estrogen–histamine feedback-loop theory goes further than current human evidence can prove.

Man experiencing heartburn after a meal in a restaurant
Upper GI, Reflux & Swallowing

Histamine and Acid Reflux: What the Evidence Actually Shows

Histamine helps control stomach acid through H2 receptors, but that does not mean histamine intolerance is an established cause of GERD.

Woman feeling dizzy after a meal with postprandial hypotension symptoms
Dysautonomia & POTS

Postprandial Hypotension: Symptoms, Causes, Diagnosis and Treatment

A drop in blood pressure after eating can cause sleepiness, dizziness or fainting, especially in older adults and people with autonomic dysfunction.

Patient having standing heart rate and blood pressure checked during POTS evaluation
Dysautonomia & POTS

MCAS and POTS: Symptoms, Testing and What the Evidence Shows

POTS and MCAS can coexist, but current research does not establish that one causes the other or that MCAS is unusually common in...

Dermatographia skin writing with raised linear hives on the forearm
Environmental & Physical Triggers

Dermatographia (Dermographism): Symptoms, Causes, Testing and Treatment

Dermatographia, also called dermographism or skin writing, produces raised linear wheals after rubbing, scratching or pressure, and the itchy, recurrent form is called...

Woman with hyperadrenergic POTS symptoms feeling dizzy while standing
Dysautonomia & POTS

Hyperadrenergic POTS: Symptoms, Diagnosis and Treatment

Hyperadrenergic POTS describes a POTS phenotype with excessive sympathetic activation, often including raised upright norepinephrine or blood-pressure responses, though phenotype boundaries can overlap.